{"id":1405,"date":"2025-02-06T18:00:15","date_gmt":"2025-02-06T18:00:15","guid":{"rendered":"https:\/\/www.infinovabio.com\/?page_id=1405"},"modified":"2025-07-19T23:38:42","modified_gmt":"2025-07-19T23:38:42","slug":"science","status":"publish","type":"page","link":"https:\/\/www.infinovabio.com\/index.php\/science\/","title":{"rendered":"Science"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1405\" class=\"elementor elementor-1405\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f47e99a e-flex e-con-boxed e-con e-parent\" data-id=\"f47e99a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;none&quot;,&quot;animation_delay&quot;:0}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ea3f02 elementor-widget elementor-widget-heading\" data-id=\"9ea3f02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our Science<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eeb0aa0 elementor-fixed elementor-widget elementor-widget-image\" data-id=\"eeb0aa0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;fixed&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1500\" height=\"1500\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7.png\" class=\"attachment-full size-full wp-image-970\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7.png 1500w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7-300x300.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7-1024x1024.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7-150x150.png 150w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/Untitled-design-7-768x768.png 768w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6d283c1 e-flex e-con-boxed e-con e-parent\" data-id=\"6d283c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_offset&quot;:60,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;],&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3d23d92 e-con-full e-flex e-con e-child\" data-id=\"3d23d92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f274128 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"f274128\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#unmet-need\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">The Unmet Need<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6e4fbb7 e-con-full e-flex e-con e-child\" data-id=\"6e4fbb7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83d1434 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"83d1434\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#the-reason\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">The Reason<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b056d0 e-con-full e-flex e-con e-child\" data-id=\"4b056d0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e88b2aa elementor-align-center elementor-widget elementor-widget-button\" data-id=\"e88b2aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#our-solution\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Our Approach<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d2b2974 e-con-full e-flex e-con e-child\" data-id=\"d2b2974\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33d6dfa elementor-align-center elementor-widget elementor-widget-button\" data-id=\"33d6dfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#result\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">The Result<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2a48ab3 e-flex e-con-boxed e-con e-parent\" data-id=\"2a48ab3\" data-element_type=\"container\" data-e-type=\"container\" id=\"unmet-need\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0b0d04f elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"0b0d04f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The Unmet Medical Need<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-054f43f elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"054f43f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Glioblastoma (GBM) is one of the most aggressive and lethal brain cancers, with a median survival of just 14-15 months and a five-year survival rate of less than 10%. Despite the fact that patients receive intense treatment regimens consisting of surgery, radiation, and chemotherapy, recurrence is nearly inevitable and, sadly, most patients eventually succumb to the disease. GBM\u2019s devastating prognosis highlights the urgent need for innovative therapies that can improve survival outcomes and quality of life for patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-87ee5f6 e-flex e-con-boxed e-con e-parent\" data-id=\"87ee5f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-567580e e-con-full e-flex e-con e-child\" data-id=\"567580e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-52b4ae4 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"52b4ae4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"575\" height=\"544\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/patients-a-year.png\" class=\"attachment-large size-large wp-image-1482\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/patients-a-year.png 575w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/patients-a-year-300x284.png 300w\" sizes=\"(max-width: 575px) 100vw, 575px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bae6d6e elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"bae6d6e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_delay&quot;:0}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Roughly 15,000 people are diagnosed with glioblastoma in the U.S. every year, accounting for half of all adult brain cancers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6f6f9b7 e-con-full e-flex e-con e-child\" data-id=\"6f6f9b7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-48fbf92 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"48fbf92\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"633\" height=\"648\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/gbm-deaths.png\" class=\"attachment-large size-large wp-image-1481\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/gbm-deaths.png 633w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/gbm-deaths-293x300.png 293w\" sizes=\"(max-width: 633px) 100vw, 633px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-885cd0c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"885cd0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_delay&quot;:0}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>About 12,000 people die of GBM each year in the U.S. &#8211; the majority of deaths caused by primary malignant brain tumors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bb05a74 e-flex e-con-boxed e-con e-parent\" data-id=\"bb05a74\" data-element_type=\"container\" data-e-type=\"container\" id=\"the-reason\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6a0d31f elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"6a0d31f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The Reason: Challenges in Drug Delivery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-355a61c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"355a61c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The challenge of GBM treatment boils down to two things:<\/p><p>First, the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB) represent formidable obstacles to effective drug delivery. These barriers restrict over 98% of therapeutic molecules from entering the brain, limiting treatment options to a handful of FDA-approved drugs. Then, to make things worse, even when drugs do cross the BBB, their penetration into the dense and hypoxic GBM tissue remains inadequate. This <b>dual challenge<\/b> has stymied progress in GBM treatment for decades, leaving patients with limited therapeutic options and poor outcomes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5775cb8 e-flex e-con-boxed e-con e-parent\" data-id=\"5775cb8\" data-element_type=\"container\" data-e-type=\"container\" id=\"our-solution\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36d5bde elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"36d5bde\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><b>Our Approach: <\/b>Drug-Loaded CAR-Neutrophils<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6e0ef6 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d6e0ef6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We have developed a single, elegant solution that simultaneously overcomes both of these issues and is extremely efficient at delivering highly potent therapeutic compounds deep into glioblastoma tumors: <b>drug-loaded CAR-neutrophils<\/b>.<\/p><p style=\"font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 300; font-size: 24px; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';\">We start by engineering human pluripotent stem cells (hPSCs) to express the appropriate chimeric antigen receptor. These are differentiated to produce large quantities of CAR-expressing neutrophils (CAR-NEs) that are then loaded with drug-conjugated nanoparticles and infused intravenously.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d95746b elementor-widget elementor-widget-image\" data-id=\"d95746b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1094\" height=\"658\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/car-NEs3-1-e1739391819153.png\" class=\"attachment-full size-full wp-image-1503\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/car-NEs3-1-e1739391819153.png 1094w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/car-NEs3-1-e1739391819153-300x180.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/car-NEs3-1-e1739391819153-1024x616.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/car-NEs3-1-e1739391819153-768x462.png 768w\" sizes=\"(max-width: 1094px) 100vw, 1094px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7312241 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7312241\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: var(--theme-letter-spacing); text-transform: var(--theme-text-transform);\">This platform is built on&nbsp;<\/span><b style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: var(--theme-letter-spacing); text-transform: var(--theme-text-transform);\">three key components<\/b><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: var(--theme-letter-spacing); text-transform: var(--theme-text-transform);\">, each playing a critical role in its overall therapeutic effectiveness.<\/span><\/p>\n<p>Explore the biological purpose and therapeutic advantages of the three components, <b>below<\/b>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fec2d24 e-flex e-con-boxed e-con e-parent\" data-id=\"fec2d24\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;arrow&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 700 10\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M350,10L340,0h20L350,10z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb62f7e e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"bb62f7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;horizontal_scroll&quot;:&quot;disable&quot;}\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"196489086\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-1964890861\" data-tab-title-id=\"e-n-tab-title-1964890861\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-1964890861\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t1. hPSC-Derived Neutrophils\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1964890862\" data-tab-title-id=\"e-n-tab-title-1964890862\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1964890862\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t2. CLTX-Based CAR\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1964890863\" data-tab-title-id=\"e-n-tab-title-1964890863\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1964890863\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t3. Drug-Loaded SiO2 Nanoparticles\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-1964890861\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1964890861\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-9c8305e e-con-full e-flex e-con e-child\" data-id=\"9c8305e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-ed6db15 e-con-full e-flex e-con e-child\" data-id=\"ed6db15\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8e5174 elementor-widget elementor-widget-heading\" data-id=\"a8e5174\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">1. hPSC-Derived Neutrophils<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c254eef elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c254eef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We have chosen to pursue a neutrophil-based drug delivery platform because these cells possess <b>three key characteristics<\/b> that make them the perfect solution to the challenges facing glioblastoma treatment.<\/p><p><b>i)<\/b>\u00a0Neutrophils naturally possess the ability to cross the BBB.<\/p><p><b>ii)<\/b>\u00a0They are actively recruited into the tumor microenvironment (TME) by inflammatory signals released by cancer cells, allowing them to penetrate deep into glioblastoma tissue.<\/p><p><b style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">iii)<\/b><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">\u00a0They can b<\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">e loaded with therapeutic agents, transforming them into <\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"><b>living drug carriers<\/b><\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">.<\/span><\/p><p><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">This unique combination makes them an ideal platform for delivering anti-cancer drugs to glioblastoma.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6402ee8 e-con-full e-flex e-con e-child\" data-id=\"6402ee8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-324e148 elementor-widget elementor-widget-image\" data-id=\"324e148\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2665\" height=\"1278\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin.png\" class=\"attachment-full size-full wp-image-1505\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin.png 2665w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin-300x144.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin-1024x491.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin-768x368.png 768w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin-1536x737.png 1536w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/ne-can-getin-2048x982.png 2048w\" sizes=\"(max-width: 2665px) 100vw, 2665px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c20c533 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c20c533\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#generation\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-arrow-circle-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M256 8c137 0 248 111 248 248S393 504 256 504 8 393 8 256 119 8 256 8zm-28.9 143.6l75.5 72.4H120c-13.3 0-24 10.7-24 24v16c0 13.3 10.7 24 24 24h182.6l-75.5 72.4c-9.7 9.3-9.9 24.8-.4 34.3l11 10.9c9.4 9.4 24.6 9.4 33.9 0L404.3 273c9.4-9.4 9.4-24.6 0-33.9L271.6 106.3c-9.4-9.4-24.6-9.4-33.9 0l-11 10.9c-9.5 9.6-9.3 25.1.4 34.4z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Learn more about our cell generation platform<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1964890862\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1964890862\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-429370d e-con-full e-flex e-con e-child\" data-id=\"429370d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-87b9a05 e-con-full e-flex e-con e-child\" data-id=\"87b9a05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e9513e5 elementor-widget elementor-widget-heading\" data-id=\"e9513e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">2. CLTX-Based Chimeric Antigen Receptor<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4897264 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4897264\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>While it is true that neutrophils harbor many therapeutically advantageous characteristics, they have a pretty significant drawback:&nbsp;<\/p>\n<p>Once inside the tumor, <b>they tend to become highly immunosuppressive<\/b> and instead of killing cancer cells, begin to help the cancer grow.<\/p>\n<p>This is obviously not good and poses a major hurdle to using them as an anti-cancer therapy. So, to prevent this, we express a chlorotoxin-based CAR on our neutrophils &#8211; these are termed <b>CLTX-CAR-NEs<\/b>.<\/p>\n<p>CLTX binds to MMP2, which is highly expressed on the surface of many GBM cells.&nbsp;<span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">When the CLTX-CAR-NEs get inside the tumor, the CAR will bind to MMP2-positive GBM cells, send stimulatory signals to the neutrophil, and prevent it from becoming immunosuppressive.<\/span><\/p>\n<p><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">Our preclinical data has shown that the CLTX-CAR is essential for maintaining the anti-cancer functionality of the neutrophils.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a42ed60 e-con-full e-flex e-con e-child\" data-id=\"a42ed60\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-387381a elementor-widget elementor-widget-image\" data-id=\"387381a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1250\" height=\"1100\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/active_NE.png\" class=\"attachment-full size-full wp-image-1519\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/active_NE.png 1250w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/active_NE-300x264.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/active_NE-1024x901.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/active_NE-768x676.png 768w\" sizes=\"(max-width: 1250px) 100vw, 1250px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1964890863\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1964890863\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-63be25d e-con-full e-flex e-con e-child\" data-id=\"63be25d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-af6a21e e-con-full e-flex e-con e-child\" data-id=\"af6a21e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b6dc5af elementor-widget elementor-widget-heading\" data-id=\"b6dc5af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">3. TPZ-Loaded SiO2 Nanoparticles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ef0180 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1ef0180\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We have strategically chosen to use Tirapazamine (TPZ)-loaded SiO2 nanoparticles for two reasons:\u00a0<\/p><p><strong>i)<\/strong> SiO2 nanoparticles\u00a0<span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">preferentially degrade within cancer cells<\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"> due to the high levels of glutathione. This way, even if the nanoparticles get into a non-cancerous cell, the drug remains encapsulated and won&#8217;t harm the healthy cell.<\/span><\/p><p><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"><strong>ii)<\/strong> <\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">TPZ is a &#8220;hypoxia-induced prodrug&#8221; meaning that it only becomes active in low-oxygen conditions<\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"> &#8211;<\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"> a very common characteristic of GBM. So, even if the nanoparticles were to get into healthy tissue, and somehow release TPZ, the drug wouldn&#8217;t be active, further reducing the potential for off-target toxicities.<\/span><\/p><p><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">This highly strategic design makes this therapeutic <\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"><b>incredibly <\/b><\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\"><b>safe to healthy cells while selectively targeting hypoxic GBM tissue<\/b><\/span><span style=\"font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit; font-weight: inherit; color: var( --e-global-color-d1991fb ); letter-spacing: 0.4px; text-transform: var(--theme-text-transform);\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8d60f84 e-con-full e-flex e-con e-child\" data-id=\"8d60f84\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-861a5c2 elementor-widget elementor-widget-image\" data-id=\"861a5c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1250\" height=\"843\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/sio2.png\" class=\"attachment-full size-full wp-image-1530\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/sio2.png 1250w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/sio2-300x202.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/sio2-1024x691.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/sio2-768x518.png 768w\" sizes=\"(max-width: 1250px) 100vw, 1250px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-526da2a e-flex e-con-boxed e-con e-parent\" data-id=\"526da2a\" data-element_type=\"container\" data-e-type=\"container\" id=\"result\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5680b36 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"5680b36\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><b>The Result: <\/b>A<b> <\/b>Highly Potent and Safe Cell-Based Therapy for GBM<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-07e67af elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"07e67af\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Together, these three components synergize to produce a highly potent cell-based drug delivery platform that is designed to selectively target deep-seeded hypoxic GBM tissue.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0d8ba elementor-widget elementor-widget-image\" data-id=\"7a0d8ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"666\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/CAR-NEs-inside-tumor-1024x666.png\" class=\"attachment-large size-large wp-image-1544\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/CAR-NEs-inside-tumor-1024x666.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/CAR-NEs-inside-tumor-300x195.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/CAR-NEs-inside-tumor-768x499.png 768w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/CAR-NEs-inside-tumor.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d33cf4c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d33cf4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Inside the body, our drug-loaded CAR-NEs cross the BBB and infiltrate deep into the core of glioblastoma tumors. Once inside, CAR-NEs behave like any normal neutrophil, targeting and killing cancer cells through a variety of mechanisms. Then, when they die, they release their cytotoxic payload, inducing incredibly potent anti-cancer effects with very little risk of toxicities.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-97f8ebc e-flex e-con-boxed e-con e-parent\" data-id=\"97f8ebc\" data-element_type=\"container\" data-e-type=\"container\" id=\"generation\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5d9fd53 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"5d9fd53\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><b>Our Cell Generation Platform<\/b><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-beb5fca elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"beb5fca\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our cell therapy platform integrates advanced stem cell technology, genetic engineering, and nanotechnology to create a highly effective drug delivery system for glioblastoma.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f49f903 elementor-widget elementor-widget-image\" data-id=\"f49f903\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1500\" height=\"644\" src=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/cell-generation-platform.png\" class=\"attachment-full size-full wp-image-1552\" alt=\"\" srcset=\"https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/cell-generation-platform.png 1500w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/cell-generation-platform-300x129.png 300w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/cell-generation-platform-1024x440.png 1024w, https:\/\/www.infinovabio.com\/wp-content\/uploads\/2025\/02\/cell-generation-platform-768x330.png 768w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19f965a elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"19f965a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We start with human pluripotent stem cells (hPSCs) that we then genetically engineer to express a chlorotoxin-based chimeric antigen receptor (CLTX-CAR) for tumor specificity and anti-cancer functionality. These engineered hPSCs are then differentiated into CAR-neutrophils using a proprietary, chemically-defined differentiation protocol.<\/p><p>Simultaneously, silicon oxide (SiO2) nanoparticles are loaded with tirapazamine (TPZ) (it is possible to load other therapeutic compounds here as well). Once the neutrophils are fully differentiated, they readily phagocytose the SiO2 nanoparticles, transforming into living drug carriers capable of crossing the blood-brain barrier and delivering therapeutics deep into tumor tissue.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c54fd31 e-flex e-con-boxed e-con e-parent\" data-id=\"c54fd31\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;triangle&quot;,&quot;shape_divider_bottom&quot;:&quot;triangle&quot;,&quot;shape_divider_bottom_negative&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500,98.9L0,6.1V0h1000v6.1L500,98.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"true\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M500.2,94.7L0,0v100h1000V0L500.2,94.7z\"\/>\n<\/svg>\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-24d4655 e-con-full e-flex e-con e-child\" data-id=\"24d4655\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dc49877 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"dc49877\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Invest in Infinova<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dfa559 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3dfa559\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>As an investor, you\u2019ll have the opportunity to support a paradigm-shifting therapeutic approach that addresses critical unmet needs, offering hope to patients and significant potential for impact. Together, we can drive innovation, advance science, and make a lasting difference in the fight against one of the most devastating cancers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aa62621 e-con-full e-flex e-con e-child\" data-id=\"aa62621\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-680b0ce elementor-align-center elementor-invisible elementor-widget elementor-widget-button\" data-id=\"680b0ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm elementor-animation-grow\" href=\"https:\/\/www.infinovabio.com\/index.php\/investors\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Investor Hub<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e4fb29a e-flex e-con-boxed e-con e-parent\" data-id=\"e4fb29a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-19e04dc elementor-widget elementor-widget-heading\" data-id=\"19e04dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Useful Links<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eb5040d e-flex e-con-boxed e-con e-parent\" data-id=\"eb5040d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-04ef60b e-con-full e-transform e-flex e-con e-child\" data-id=\"04ef60b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_transform_scale_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.0500000000000000444089209850062616169452667236328125,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fc7c2e7 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"fc7c2e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-team2\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tAbout Us\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tLearn about our mission, discover the philosophy at the heart of our therapeutic approach, and meet the Infinova team.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aa8a04b elementor-align-center elementor-widget elementor-widget-button\" data-id=\"aa8a04b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.infinovabio.com\/index.php\/company\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">About Us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b068501 e-con-full e-transform e-flex e-con e-child\" data-id=\"b068501\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_transform_scale_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.0500000000000000444089209850062616169452667236328125,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96c5ef5 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"96c5ef5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-monitor\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tNews and Media\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tCheck out the media center to keep up with our latest news and our upcoming events.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8241b34 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"8241b34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.infinovabio.com\/index.php\/news-media\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Media Center<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-05d7333 e-con-full e-transform e-flex e-con e-child\" data-id=\"05d7333\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_transform_scale_effect_hover&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1.0500000000000000444089209850062616169452667236328125,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;_transform_scale_effect_hover_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47f38b8 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"47f38b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-message\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tContact Us\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tFeel free to reach out and ask any questions or express any concerns. We believe in open dialogue.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0678128 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"0678128\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.infinovabio.com\/index.php\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact Us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Our Science The Unmet Need The Reason Our Approach The Result The Unmet Medical Need Glioblastoma (GBM) is one of the most aggressive and lethal brain cancers, with a median survival of just 14-15 months and a five-year survival rate of less than 10%. 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