We’re initially advancing our CAR-NE platform in glioblastoma – one of the most aggressive and treatment-resistant solid tumors – where the need for effective drug delivery is especially urgent.
Given the platform’s ability to penetrate dense tumor tissue, we see broad potential across multiple solid tumor types, including those traditionally excluded from immune-based therapies.
While neutrophils naturally infiltrate tumors, they often become immunosuppressive once inside, promoting tumor growth rather than fighting it.
To prevent this, we engineer our neutrophils with a chlorotoxin-based CAR (CLTX-CAR), which targets MMP2 on GBM cells and preserves their anti-tumor function.
TPZ-Loaded SiO2 Nanoparticles
We use TPZ-loaded SiO₂ nanoparticles for their dual selectivity.
SiO₂ degrades preferentially in cancer cells, while TPZ only activates under hypoxic conditions – common in GBM but rare in healthy tissue.
This design maximizes tumor targeting while minimizing off-target toxicity.